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KMID : 1098420140220010046
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Korean Journal of Medicinal Crop Science
2014 Volume.22 No. 1 p.46 ~ p.52
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Neuroprotective Effects of the Extracts from the Aerial Parts of Carthamus tinctorius L. on Transient Cerebral Global Ischemia in Rats
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Kim Young-Ock
Lee Sang-Won
Yang Seung-Ok
Na Sae-Won
Kim Soo-Kang
Chung Joo-Ho
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Abstract
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In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of central nervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower could
influence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day (200 ㎎/㎏ body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brain ischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreased the induction/reduction - induced production of neuronal cell loss from global cerebral ischemia. Safflower markedly decreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances
(TBARS) (55.2 ± 9.4 μmol mg-1) and significant improvement of activities of glutathione (GSH) (27.2 ± 5.0 μmol mg-1) in
hippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell loss
induced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment of vascular dementia.
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KEYWORD
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Carthamus tinctorius L, Ischemia, Cognitive, Memory
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